Research Progress of Proliferating Cell Nuclear Antigen Inhibitors

Malignant tumors endanger the lives of many people. The abnormal expression of proliferating cell nuclear antigen(PCNA) in different malignant tumors is related to the proliferation, prognosis and detection of tumor cells. PCNA can be used as an ideal target for the treatment of malignant tumors. A new anticancer pathway can be found through the inhibition of PCNA, which plays an important role in the treatment of many kinds of malignant tumors. The discovery of "anticancer drug" AOH1996 marks a great progress in specifically targeting PCNA. The exploration of efficient and safe PCNA inhibitors has attracted more and more attention. Based on the relationship between PCNA and tumor, this paper summarizes the structural characteristics, mechanism of action and anticancer activity of PCNA inhibitors.