Optimization of Synthesis Process of 2-Methoxycinnamaldehyde Based on Box-Behnken Response Surface Methodology

OBJECTIVE To optimize the synthesis process of 2-methoxycinnamaldehyde by Box-Behnken response surface methodology.

METHODS On the basis of single factor experiments, a Box-Behnken central combination design experimental scheme was adopted, with the yield of 2-methoxycinnamaldehyde as the response value, the catalyst dosage, KOH dosage and reaction time as independent variables. Then a mathematical model was established to optimize and analyze the process conditions.

RESULTS The order of factors affecting the response value was catalyst dosage, reaction time, and KOH dosage. The optimal conditions for the synthesis of 2-methoxycinnamaldehyde from 0.5 g O-anisaldehyde and 0.30 g acetaldehyde were obtained as follows: reaction time 2 h, catalyst benzyltriethylammonium chloride 4 mg, 0.2 g·mL⁻¹ KOH 0.2 mL(40 mg KOH). Under this condition, the yield of 2-methoxycinnamaldehyde was 49.60%, and the model predicted a yield of 46.55% with an absolute deviation of 3.05%.

CONCLUSION The model established by this research is reliable and effective for optimizing the synthesis process of 2-methoxycinnamaldehyde.