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    SHA Sha, WU Lisha, LIU Guiyong, GUO Wei, WANG Yingxin, YAN Shiqiang. Study on Preparation, Characterization and Properties of Deferasirox-Nicotinamide Co-crystal[J]. Chinese Journal of Modern Applied Pharmacy, 2025, 42(6): 965-969. DOI: 10.13748/j.cnki.issn1007-7693.20233324
    Citation: SHA Sha, WU Lisha, LIU Guiyong, GUO Wei, WANG Yingxin, YAN Shiqiang. Study on Preparation, Characterization and Properties of Deferasirox-Nicotinamide Co-crystal[J]. Chinese Journal of Modern Applied Pharmacy, 2025, 42(6): 965-969. DOI: 10.13748/j.cnki.issn1007-7693.20233324
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    Study on Preparation, Characterization and Properties of Deferasirox-Nicotinamide Co-crystal

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      • Abstract
    • OBJECTIVE To prepare deferasirox-nicotinamide co-crystal(molar ratio 1∶1), improve the solubility of deferasirox.
      METHODS The deferasirox-nicotinamide co-crystal was prepared by the grinding method using deferasirox and nicotinamide as the raw materials. The structure of co-crystal was characterized by 1H-NMR, power X-ray diffraction, differential scanning calorimetry, thermal gravimetric analysis and fourier transform infrared spectrum, respectively. The solubility, stability and hygroscopicity of the co-crystal were also studied.
      RESULTS The solubility of co-crystal in water was increased to 27 times as compared with deferasirox.
      CONCLUSION The physical and chemical properties of deferasirox-nicotinamide pharmaceutical co-crystal are good.
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