A Case Report and Literature Review of A Child with Refractory Anti-<i>N</i>-methyl-<i>D</i>-aspartate Receptor Encephalitis Treated with Tocilizumab

ZHANG Weiqin; ZHAO Huawei; WANG Zhenzhen; GAO Feng; YUAN Zhefeng

doi:10.13748/j.cnki.issn1007-7693.20232480

ZHANG Weiqin, ZHAO Huawei, WANG Zhenzhen, GAO Feng, YUAN Zhefeng. A Case Report and Literature Review of A Child with Refractory Anti-N-methyl-D-aspartate Receptor Encephalitis Treated with Tocilizumab[J]. Chinese Journal of Modern Applied Pharmacy, 2024, 41(6): 834-838. DOI: 10.13748/j.cnki.issn1007-7693.20232480

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A Case Report and Literature Review of A Child with Refractory Anti-N-methyl-D-aspartate Receptor Encephalitis Treated with Tocilizumab

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OBJECTIVE To explore the safety and efficacy of tocilizumab in the treatment of refractory anti-N-methyl-D-aspartate receptor encephalitis in children, and to provide reference for the treatment of this disease.
METHODS The clinical manifestations, diagnosis and treatment, safety and efficacy of tocilizumab in a case of refractory anti-NMDAR encephalitis in Children’s Hospital, Zhejiang University School of Medicine were analyzed retrospectively, and the relevant literature was reviewed.
RESULTS The clinical symptoms of the patient were not improved after 2 doses of methylprednisolone, immunoglobulin and 6 doses of rituximab. After 6 doses of tocilizumab, the modified Rankin scale(mRS) score was improved without adverse reactions.
CONCLUSION Tocilizumab, as a escalation second-line immunotherapy, is effective and well tolerated in the treatment of refractory anti-NMDAR encephalitis. It is one of the potential therapeutic means.

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A Case Report and Literature Review of A Child with Refractory Anti-N-methyl-D-aspartate Receptor Encephalitis Treated with Tocilizumab

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