Advancements in Nasal-to-Brain Drug Delivery for the Treatment of Neurological Disorders

The development of drugs targeting the nervous system is urgently needed. However, the presence of the blood-brain barrier poses a significant challenge as it restricts the entry of drugs into the brain, limiting their therapeutic efficacy and impeding drug development and clinical applications. Nasal-to-brain drug delivery is an emerging application of nasal products, which aims to deliver drugs to the brain through intranasal administration. This paper aims to provide an overview of the main mechanisms, advantages, and challenges associated with nasal-to-brain delivery, as well as discuss the current status and advancements of clinical research on nasal-to-brain drug delivery, providing valuable insights for the clinical development and appplications of nasal products used in the treatment of neurological disorders.