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    PENG Xin, ZHANG Bingsong, DENG Zebang, HUANG Zhigang. Pharmacokinetic Parameters Calculation and Bioequivalence Analysis Based on SAS, R and WinNonLin Software[J]. Chinese Journal of Modern Applied Pharmacy, 2024, 41(16): 2270-2275. DOI: 10.13748/j.cnki.issn1007-7693.20230783
    Citation: PENG Xin, ZHANG Bingsong, DENG Zebang, HUANG Zhigang. Pharmacokinetic Parameters Calculation and Bioequivalence Analysis Based on SAS, R and WinNonLin Software[J]. Chinese Journal of Modern Applied Pharmacy, 2024, 41(16): 2270-2275. DOI: 10.13748/j.cnki.issn1007-7693.20230783
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    Pharmacokinetic Parameters Calculation and Bioequivalence Analysis Based on SAS, R and WinNonLin Software

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      • Abstract
    • OBJECTIVE To calculate pharmacokinetic parameters and bioequivalence analysis through SAS, R, and WinNonL in software.
      METHODS The SAS "proc reg" and "proc mixed" procedures, the R "NonCompart" and "nlme" packages, and WinNonLin software were used to calculate pharmacokinetic parameters and construct a linear mixed-effects model. Used two one-sided t-tests and the 90% confidence interval to determine bioequivalence.
      RESULTS The pharmacokinetic parameters and bioequivalence results calculated using SAS, R and WinNonLin software were consistent.
      CONCLUSION The pharmacokinetic parameters calculation and bioequivalence analysis can be achieved through SAS, R, and WinNonLin software with accurate and reliable result.
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