LI Xuanwei, LIN Meihua, ZHAI You, XU Nana, LI Xiao, LYU Duo, ZHAO Qingwei, LIU Jian. Clinical Consistency Evaluation of Quetiapine Kit Based on Liquid Chromatography Tandem Mass Spectrometry Technology[J]. Chinese Journal of Modern Applied Pharmacy, 2024, 41(13): 1803-1807. DOI: 10.13748/j.cnki.issn1007-7693.20230211
    Citation: LI Xuanwei, LIN Meihua, ZHAI You, XU Nana, LI Xiao, LYU Duo, ZHAO Qingwei, LIU Jian. Clinical Consistency Evaluation of Quetiapine Kit Based on Liquid Chromatography Tandem Mass Spectrometry Technology[J]. Chinese Journal of Modern Applied Pharmacy, 2024, 41(13): 1803-1807. DOI: 10.13748/j.cnki.issn1007-7693.20230211

    Clinical Consistency Evaluation of Quetiapine Kit Based on Liquid Chromatography Tandem Mass Spectrometry Technology

    • OBJECTIVE  To evaluate the consistency between the quetiapine LC-MS/MS kit and the laboratory-built method(reference method) in the detection results of quetiapine therapeutic drug monitoring.
      METHODS  A total of 120 remaining plasma samples were collected from patients receiving quetiapine therapeutic drug monitoring from March to October in 2021. The plasma concentration of quetiapine was detected by kit and reference method respectively. The analysis of correlations and consistency was performed by outlier analysis, linear regression and Bland-Altman method.
      RESULTS  No outliers were detected. The linear regression equation was Y=1.018X+4.400(r=0.998), indicating a good correlation. The Bland-Altman plot analysis showed good agreement between the two measurements.
      CONCLUSION  The detection results of quetiapine LC-MS/MS kit and reference method are in good agreement. The kit can be used for clinical quetiapine treatment drug monitoring.
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