Establishment and Application of Special Evaluation Method for Omeprazole Sodium for Injection Based on Weighted TOPSIS Method

OBJECTIVE To establish the criteria of evaluating the rationality of technique for order of preference by similarity to ideal solution(TOPSIS) intravenous omeprazole based on use drug use evaluation(DUE). And to provide reference guidance to the special evaluation of proton pump inhibitors. METHODS According to the national guidelines, drug instructions and consensus guidelines, the rationality evaluation criteria of omeprazole sodium for injection were formulated. Medical records of omeprazole sodium for injection from January to June 2021 were used as the control group, and medical records from July to December were used as the observation group. The relative proximity(C_i) between evaluated medical record and the rational solution was calculated by using TOPSIS method. If the C_i was ≥80%, categorized it as rational medication. If the C_i was <60%, categorized it as irrational medication. Any number between 80% and 60%, categorized it as nearly rational medication. χ² test was utilized to analyze the rate of rational medication between observational group and control group. RESULTS Among the 218 cases of control group, relative proximity(C_i) of 71 cases(32.57%) was ≥80%, that of 128 cases(58.71%) was 60%≤C_i<80%, and that of 19 cases(8.72%) was <60%. Among the 229 cases of observational group, C_i of 118 cases(51.53%) was ≥80%, that of 104 cases(45.41%) was 60%≤C_i<80%, and that of 7 cases(3.06%) <60%. Compared with the control group, the observation group had statistically significant differences in terms of indications, dosage, course of treatment, pharmaceutical monitoring and drug use beyond the medical insurance limit. CONCLUSION The special evaluation of omeprazole sodium for injection based on the weighted TOPSIS method is reasonable and feasible, which can reduce the subjective evaluation of the evaluation personnel, and can provide a reference for strengthening the strength and depth of the evaluation of medical orders and achieving standardized special evaluation.