Meta analysis of the Effects of Omeprazole and Lansoprazole in the treatment of Gastroesophageal Reflux Disease

OBJECTIVE To systematically evaluate the clinical efficacy of omeprazole and lansoprazole in the treatment of gastroesophageal reflux disease, aiming to provide data support for the selection of clinical treatment options for gastroesophageal reflux disease. METHODS Based on topics such as gastroesophageal reflux disease, omeprazole and lansoprazole, searched well-known databases such as CNKI, Wanfang, PubMed, Weipu, Longyuan, etc., screened and finally included 12 articles. Among them, the observation group was treated with oral lansoprazole sustained-release capsules, and the control group was treated with oral omeprazole enteric-coated capsules. The total effective rate, incidence of adverse reactions, symptom relief, and healing rate under gastroscopy were used as four indicators with systematic analysis. RESULTS The total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant(OR=7.09, 95%CI: 3.48-14.46, Z=5.39, P<0.00001); the incidence of adverse reactions in the observation group was significantly lower than that of the control group, the difference was statistically significant(OR=0.31, 95%CI: 0.19-0.50, Z=4.83, P<0.00001); the symptom relief of the observation group was significantly better than that of the control group, and the difference was statistically significant(OR=3.64, 95%CI: 1.97-6.74, Z=4.11, P<0.00001); the healing rate under gastroscopy in the observation group was significantly higher than that in the control group, and the difference was statistically significant(OR=2.66, 95%CI: 1.66-4.25, Z=4.09, P<0.00001). CONCLUSION Compared with omeprazole treatment, lansoprazole is more effective in the treatment of gastroesophageal reflux disease, has fewer adverse reactions, is safe and reliable, and can effectively relieve patients’ clinical symptoms and promote recovery.