Analysis of Influencing Factors of Doxofylline Blood Concentration in Male Patients with COPD and Renal Impairment

OBJECTIVE To analyze the monitoring results of doxofylline blood concentration in male patients with chronic obstructive pulmonary disease and renal impairment, and explore the influencing factors of doxofylline blood concentration. METHODS A retrospective analysis was used to collect 121 male patients with chronic obstructive pulmonary disease and renal impairment in Zhengzhou Second Hospital from July 2018 to July 2021, recorded the blood concentration monitoring results, patient demographic data, examination indicators and combined medication. Univariate analysis was performed to initially explore the association of possible influencing factors and the concentration of blood drugs. Factors were included to construct a multivariate linear regression model to correct for the effects of confounders. RESULTS Univariate results showed that the blood concentration of doxofylline was correlated with age(r=0.32, P<0.001), body weight(r=-0.40, P<0.001), and glomerular filtration rate(r=-0.24, P=0.008), the association was statistically significant. Compared with patients with severe renal impairment, patients with mild impairment had lower doxofylline plasma concentrations(P=0.017), and smoking patients had lower doxofylline plasma concentrations(P=0.018). After adjusting for other factors, the results showed that the older the age, the higher the blood drug concentration(b=0.08, P=0.032 the smoking patients), the heavier the weight, the lower the blood drug concentration(b=-0.14, P<0.001), and blood levels of the smoking patients were lower than those of non-smokers(b=-1.30, P=0.048). CONCLUSION For male patients with chronic obstructive pulmonary disease with renal impairment, the plasma concentration of doxofylline is related to various factors. Older, lighter, and lower GFR patients has higher plasma concentrations, and smoking may lead to lower doxofylline plasma concentrations.