Research Progress on Pharmacodynamic Substances and Mechanism of Anemarrhenae Rhizoma- Phellodendri Chinensis Cortex Herb Pair in the Treatment of Diabetic Osteoporosis

Diabetic osteoporosis is a systemic metabolic bone disease caused by long-term hyperglycemia and has become one of the major complications of diabetes. It is characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Anemarrhenae Rhizoma-Phellodendri Chinensis Cortex herb pair is a classic drug combination, and has been widely used in many anti-diabetic osteoporosis prescriptions. The pharmacological studies have shown that the effects of this herb pair on promoting formation and inhibiting bone resorption are closely related to the Nrf2, MAPK, Wnt and RANK/RANKL signaling pathways as well as autophagy. The compatibility of this herb pair changes the dissolution and pharmacokinetics of the active substances, which have synergistic effects. This article summarized the effective substances of Anemarrhenae Rhizoma-Phellodendri Chinensis Cortex and its mechanism of action against diabetes and osteoporosis, providing a reference for further research and development of the drug pair.