Research Progress of chitosan derivatives as materials for siRNA nano-delivery systems

Small interfering RNA(siRNA) has been the focus of attention in the field of drug development for its excellent properties such as efficiency, specificity and transient nature in treating diseases. However, the poor stability and low cellular uptake of naked siRNAs make it difficult for them to exert their gene silencing effects, a high-quality drug delivery system is needed to deliver them to target cells where they can function. Many nano delivery systems are no longer suitable for siRNA transport due to toxicity and drug loading problems, chitosan derivatives are beginning to receive widespread attention because of their high water solubility, safety and stability. This paper reviewed the research progress of chitosan derivatives as siRNA nano-delivery systems and provided a reference for researchers who are interested in the development of nano-delivery systems.