New Research Progress of IL-13 Activating the Goblet Cell Involved in Mucus Hypersecretion of Asthma

Bronchial asthma is an inflammatory disease of airway, and airway mucus hypersecretion caused by inflammation airway remodeling and other factors is the main pathological features of asthma. Activating goblet cells and secreting muc5ac are the key link of mucus hypersecretion in asthma. Interleukin-13(IL-13), mainly derived from Th2 cells, activates goblet cells through various signaling pathways and participates in the process of airway mucus hypersecretion in asthma. This study reviews IL-13 activated goblet cells participating in airway mucus hypersecretion in asthma in recent 5 years in order to provide theoretical basis for clinical treatment and new drug research of airway mucus hypersecretion in asthma and other respiratory diseases.