Construction of Chemical Constituents Database of Longan Arillus and Study on Network Pharmacology of Its Mechanism of Treating Anemia

OBJECTIVE To establish the chemical component database of Longan Arillus, and preliminarily explore the mechanism of Longan Arillus in the treatment of anemia combined with network pharmacology. METHODS Summarized and established a database of pharmacodynamic chemical components of Longan Arillus by literature research method. Predicted the active components in Longan Arillus through Swiss TargetPrediction, collected the target genes related to anemia using OMIM, DrugBank, GeneCards, screened the intersection targets between components and diseases, conducted protein interaction, established the "Longan Arillus-active components-target-diseases" network, GO enrichment and KEGG analysis. RESULTS The chemical composition database of Longan Arillus was established and 256 compounds were collected, including 12 saccharides, 27 polyphenols, 147 volatile components, 2 sterols, 12 organic acids, 13 lipids, 11 nucleosides, 29 amino acids, 3 other organic components and various trace elements. The 32 active ingredients were obtained after screening. There were 24 intersection targets, and TOP1, TERT, MPO, PARP1, etc. could be key targets. There were 87 biological functions, involving cytokine mediated signal pathways, positive regulation of gene expression, cytokine activity, etc. There were 15 pathways, including cancer pathway, mitogen activated protein kinase signaling pathway, base excision repair system and so on. CONCLUSION The component library of Longan Arillus has been established. Potential active ingredients, target information and action mechanism of Longan Arillus in the treatment of anemia has been preliminarily discussed. This study can provide a valuable reference for pharmacological and pharmacodynamic research and resource development of Longan Arillus.