Advance of new Anti-tuberculosis drug preparation

Tuberculosis(TB) is a chronic infectious disease caused by Mycobacterium tuberculosis(MTB). It can accumulate multiple organs, of which tuberculosis is the most common attack on the lungs. At present, the commonly used anti tuberculosis drugs are mainly oral tablets, capsules or injections, but these conventional formulations are often difficult to distribute effectively in the core lesion area of the tuberculosis, so that the drugs are distributed nonspecific to other tissues and organs through the circulation of the body, resulting in low local drug concentration and easy to produce adverse reactions, thus affecting the therapeutic effect of antitubercular drugs. Microspheres, liposomes, nanoparticles and other new dosage forms can selectively concentrate drugs on tuberculosis lesions, thereby reducing the side effects of drugs and improving patient compliance. Therefore, this article aimed to provide a comprehensive review of the correlation research on new formulations of tuberculosis drugs.