Establishment of Oxaliplatin Evaluation Criteria Based on Weighted TOPSIS Method and Drug Rationality Evaluation

OBJECTIVE To construct a drug utilization evaluation(DUE) standard for oxaliplatin based on the weighted TOPSIS method, and to discuss the rationality and standardization of its application, so as to provide a reference for doctor’s order review. METHODS Based on the oxaliplatin instruction manual, combined with relevant standards and guidelines, the DUE standard of oxaliplatin in Suzhou Hospital Affiliated to Anhui Medical University was established. The weighted TOPSIS method was used to evaluate the oxaliplatin DUE of a total of 246 cases in hospital from June to December 2019, and analysis and evaluation according to the evaluation results. RESULTS The attribute hierarchical model analysis of 11 evaluation indicators was carried out, and the results conform to the consistency test, and the corresponding weight values of the 11 items were 16.915%, 9.950%, 10.945%, 5.970%, 9.950%, 13.930%, 2.488%, 8.955%, 10.945%, 3.483%, 6.468%; in the 246 cases, the highest Ci was 100%, the lowest was 0, 200 cases(81.30%) with Ci≥80%, 24 cases(9.76%) with Ci in the range of 60% to 80%, 22 cases (8.94%) with Ci<60%; irrational drug use mainly focused on indications, conditioning regimen, administration method, dose adjustment and administration sequence. CONCLUSION Most of the patients’ oxaliplatin medication complied with the instructions and relevant guidelines or principles, and only a very small number of patients have unreasonable drug use. For medication, it is recommended to standardize medication according to the principles or guidelines and instructions for oxaliplatin medication. The evaluation results of the rationality of oxaliplatin based on the weighted TOPSIS method are intuitive and easy to operate.