Analysis of the Effect and Safety of Dexmedetomidine in Total Intravenous Anesthesia for Radical Gastrectomy

OBJECTIVE To investigate the effect and safety of dexmedetomidine in total intravenous anesthesia for radical gastrectomy. METHODS One hundred and twenty cases of patients who undergoing radical gastrectomy in Huzhou Central Hospital from July 2018 to June 2020 were selected as the research objects, and were randomly divided into control group and observation group with 60 cases each. Two groups of patients were given general anesthesia by tracheal intubation, propofol+sufentanil+ rocuronium were used for anesthesia induction in the control group, and dexmedetomidine was used in the observation group on the basis of the control group. The anesthesia excellent and good rate, vital signs, postoperative anesthesia recovery time, postoperative adverse reaction rate, cognitive function score and postoperative pain score were compared between the two groups. RESULTS There was no significant difference in the excellent and good rate of anesthesia between the two groups. Compared with before intubation, systolic blood pressure, diastolic blood pressure and heart rate of the two groups did not change significantly after intubation. After intubation, there was no significant difference in systolic blood pressure, diastolic blood pressure and heart rate between the two groups. The recovery time of spontaneous breathing, eye opening and command in the observation group were significantly shorter than those in the control group (P<0.05). The incidence of postoperative adverse reactions was 1.67% in the observation group and 11.67% in the control group, which was significantly lower than that in the control group (P<0.05). Compared with pre-operation, MMSE and MoCA scores of patients in both groups decreased significantly after operation (P<0.05). After operation, MMSE and MoCA scores of observation group were significantly higher than those of control group (P<0.05). At 4, 8, 12 h after operation, the pain scores of the observation group at rest and cough were significantly lower than those of the control group (P<0.05).CONCLUSION Dexmedetomidine in total intravenous anesthesia for radical gastrectomy can maintain the stability of patients’ vital signs, ensure good intraoperative anesthesia effect, reduce adverse reactions and achieve good postoperative analgesic effect.