Research Progress of Self-regulated Insulin Delivery Gel System

Diabetes is a global medical and health problem. At present, subcutaneous injection of insulin has some problems, such as inconvenient administration, causing pain to patients and easily causing hypoglycemia risk. Therefore, painless administration and precise release of drugs to control blood glucose are the key to the next generation of diabetes treatment. In the insulin self-adjusting system, the polymer hydrogel controlled release system can accurately control the release of insulin, monitor and control the blood glucose level in real time, which is of great significance to improve the treatment effect of diabetes. In this paper, the latest research progress of three kinds of glucose sensing insulin release gel systems at home and abroad is reviewed. The drug delivery mechanism, advantages and disadvantages of protein glucose sensing system, non protein glucose sensing system and their combination are described in detail. The research on insulin self-adjusting gel delivery system is summarized and prospected.