Simulation Study on the Regulation Mechanism and Criterion of Density Consistency in Compression Dry Granulation

OBJECTIVE To simulate and study the regulation mechanism and criteria of density consistency of compression dry granulation pressin aiming at the common problem that it is difficult to control the dissolution characteristics and consistency of compression dry granulation. METHODS Based on the Edinburgh Elastic-Plastic Adhesion contact model, the collaborative coupling simulation method integrating powder screw conveying and rolling ribbon was constructed, and the control technology was proposed in which the relative density and consistency for rolling ribbon was controlled by means of volume flow compression ratio, the regulation mechanism was explained. RESULTS A synergetic coupling linear correlation control model between average relative density and volume flow compression ratio was established, the critical volume flow compression ratio required to meet the ribbon dissolution characteristics and strength was 0.91, the synergetic coupling evolution law was revealed between the RSD of uniformity and stability and the volumetric flow compression ratio, the value space of volume flow compression ratio was 0.58 to 1.31 in which the RSD of rolling ribbon uniformity and stability was <5%. CONCLUSION The control criterion to ensure the dissolution characteristics and consistency at the same time is that the volume flow compression ratio of dry rolling granulator should be set in the value space of 0.91 to 1.31.