Study on Optimization of Preparation Process of Paclitaxel(Albumin Binding Type) for Injection

OBJECTIVE To explore the optimization effect of intelligent weighing instrument in preparing paclitaxel for injection(albumin binding type). METHODS Optimize the preparation process of paclitaxel for injection(albumin binding type) in the instruction manual, the specific optimization measures included no limit on the speed of solvent injection, simplify the static bottle for 5 min by using intelligent weighing instrument and manual shaking for 2 min. The foam height, drug preparation time and drug stability of the control group and the experimental group after drug dissolution were collected for statistical analysis before and after process optimization. RESULTS The foam height after drug dissolution was 2.80 mm in the experimental group and 3.05 mm in the control group, which was significantly lower in the experimental group than in the control group(P<0.05). The statistical results of two groups of data showed that average preparation time of each chemotherapy infusion drug was 539.79 s in the experimental group and 537.94 s in the control group, the difference was not statistically significant. The total amount per unit time was higher in the experimental group than in the control group. There was no significant difference in drug stability between the two groups. CONCLUSION The intelligent weighing instrument is applied to the preparation of paclitaxel for injection(albumin binding type), which can ensure the quality of drug configuration, improve the efficiency of configuration.