Design and Optimization of the Formulation of Tofacitinib Sustained-release Tablets with JMP Software

OBJECTIVE To screen the core formulation of tofacitinib sustained-release tablets by using the experimental design and predictive descriptor function of JMP software, and to explore the practicability of JMP software in tablet prescription screening. METHODS The powder direct compression process was adopted, the amount of excipients was screened through the experimental design, and the f₂ value of the dissolution curve of the self-made sample and the reference tablet core was used as an indicator to establish a model. Moreover, the prediction profiler of the JMP software was used to find the optimal formulation and dissolution result, and the predicted optimal formulation result was verified. RESULTS The actual test results were very close to the software prediction results. CONCLUSION The use of JMP software to design and predict formulation is simple and convenient, the prescription development process for drugs can be promoted.