Application and Practice of Intelligent Technology of Cytotoxic Drugs in Pharmacy Intravenous Admixture Services

OBJECTIVE To summarize the application of intelligent technology and equipment in the working process reengineering of cytotoxic drug in pharmacy intravenous admixture services(PIVAS), and the performance is also evaluated to provide the reference to other hospital. METHODS The application and practice of intelligent technology and equipment in PIVAS of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology were introduced. Ratio of cytotoxic drug irrational medical order after intelligent medical order review system establishing was calculated. Work efficiency and errors were compared between intelligent labeling machine and manual operation to evaluate the application effect of the equipment. Admixing speed, residual liquid and working error were used to evaluate the performance of intelligent automatic compounding robot. RESULTS The successful intervention rate of irrational medical order were gradually increased from 88.64% to 100% in three months, before and after the establishment of intelligent medical order review system. The labeling speed of intelligent labeling machine group and manual labeling group were (15.50±1.20)bag·min^-1 and (10.11±0.39)bag·min^-1 with significant difference, respectively. Less labeling errors were observed of machine group (0.41/1 000 bags) than manual labeling group(0.79/1 000 bags). Infusion compounding speed of manual compounding group was significantly higher than that of intelligent compounding robot group, were (0.49±0.07)bag·min^-1 and (0.23±0.04)bag·min^-1, respectively. However, the errors of the compounding robot group(0.30/100 bags) were less than those of the manual compounding group(0.56/100 bags). Residual liquid volume of vials and ampoules medicine compounding were also observed, the results showed that the compounding robot group(0.21±0.06)mL·vial^-1 were prior to the manual compounding group(0.46±0.23)mL·vial^-1 of vials medicine compounding, and residual liquid volume of ampoules medicine of manual compounding group(0.09±0.04)mL·vial^-1 were slightly higher than the compounding robot group(0.08±0.02)mL·vial^-1 without significant difference. CONCLUSION The working process of cytotoxic drug in PIVAS is significantly improved by establishing intelligent medical order review system and intelligent equipment. Qualify of finished infusions and working efficiency are improved and working error is reduced, which are important for PIVAS. Furthermore, the infusion compounding speed of intelligent compounding robot is slower than manual group, need to be improved in the further study.