Pharmaceutical Care of a Patient with Drug-induced Pseudomembranous Enteritis

OBJECTIVE To report a case of clinical treatment and pharmaceutical care of a patient with pseudomembranous enteritis and abdominal pain but no diarrhea to warn clinical safety.METHODS The clinical pharmacists investigated the patient’s disease history and drug treatment history, meanwhile, combined the results of colonoscopy to analyze the condition and drug characteristics, and provided treatment suggestions.RESULTS After comprehensive analysis, it was considered that the combination of broad-spectrum antibiotics and proton pump inhibitors led to Clostridium difficile infection, which was an adverse drug reaction.CONCLUSION It should pay attention to inappropriate use of antibiotics and proton pump inhibitors can cause severe Clostridium difficile infection. More attention should be paid to pseudomembrane enteritis, which has been treated with multiple antibiotics for a long time without diarrhea symptoms.