Metabolomics study of sulidate combined with montelukast sodium in the treatment of bronchial asthma

OBJECTIVE To explore the mechanism of the effects of sulidate combined with montelukast sodium on bronchial asthma based on metabolomics.METHODS A total of 140 elderly patients with bronchial asthma from May 2016 to December 2018 were treated with sulidate combined with montelukast sodium, and LC-MS/MS-based on metabolic analysis was performed to assess the therapeutic benefits of the combination medication.RESULTS Potential metabolic markers of elderly patients after treatment were zinc, dopamine, cysteine, choline, acetoacetate, homocysteine, adenine, histamine, and ornithine, and the first three substances had an upward trend, while other substances showed a downward trend. After treatment, the plasma metabolism of patients was significantly different from that before treatment.CONCLUSION sulidate combined with montelukast sodium can not only regulate the amino acid metabolism of patients with bronchial asthma, and enhance their immune function, but also improve their anti-apoptosis and anti-oxidation capabilities. It can regulate the level of neurotransmitters by inhancing ammonia transport, regulate cellular signaling, hormone levels and energy metabolism.