Current Situation and the Trend of Clinical Trials of Drugs for Treatment of Multiple Sclerosis

Multiple sclerosis is an autoimmune demyelinating disease of the central nervous system mediated by inflammatory CD4⁺ T cells,characterized by repetitive and irreversible course.Multiple sclerosis has become the main cause of young adults disability in China except trauma,and the morbidity rate among young children is increasing in these years,which has brought heavy economic burden to families and society.The disease-modifying treatments have been employed to relieve the disease by suppressing the activity of the immune system,however,there is no definite cure for multiple sclerosis currently.A number of clinical trials have been carried out to find more effective strategies for multiple sclerosis.This review provides comprehensive overview of current status,quality influencing factors and current therapies in clinical trials of multiple sclerosis treatments,and attempts to clarify the potential improvements and prospects for multiple sclerosis clinical trials.