Clinical Cases Analysis of Furazolidone-induced Acute Pulmonary Toxicity

OBJECTIVE To summarize clinical features,course and outcome of furazolidone-induced acute pulmonary reactions,and to improve the understanding of furazolidone associated the pulmonary toxicity.METHODS A retrospective analysis including clinical characteristics,laboratory tests,treatments and outcomes was made on 9 hospitalized cases of acute lung injury which were attributed to furazolidone.RESULTS Acute pulmonary reactions appeared a mean of (9.78±3.15) d after the start of furazolidone treatment,their initial manifestation was fever.Early chest imaging feature was pulmonary interstitial changes containing bilateral interlobular septa thickening,intralobular lines and intralobular interstitial thickening.Furazolidone therapy was discontinued in all patients at visit,8 cases did not receive glucocorticoid therapy.The improving rate in general was 100%,5 cases reexamining CT indicated interstitial changes were absorbed before discharge.CONCLUSION Furazolidone as an important drug for treatment of Helicobacter pylori infection may induce acute pulmonary toxicity characterized by interstitial changes,need to monitor closely,so as to find and process it timely.