Study on Prescription Analysis of Proton Pump Inhibitors Switch of 19 254 Outpatients

OBJECTIVE To provide a reference for selecting and optimizing subsequent clinical proton pump inhibitor (PPI) medication by comparing the clinical characteristics and prescription differences of outpatients with and without the PPI switch in the treatment of gastric acid-related diseases.METHODS Outpatient PPI prescriptions database was established.Inclusion criteria were:patients prescribed with more than two adult PPI prescriptions.The non-switch drug group was defined as the patients who used only one PPI,and the specifications and dosage did not change.The switch drug group was defined as patients who switched the PPI with different generic names or specifications and dosage of the same generic name.The patient proportion,duration,number of prescriptions,diagnostic result,dose intensity and the utilization of PPI between the two groups were compared.RESULTS The PPI prescription analysis result showed the proportion of switch drug group accounted for 21.90%,which was higher than that in the non-switch drug group.In the 65-79 age group,the ratio of users in the switch drug group to the non-switch drug group was 1.22(826/678).The patient proportion of gastroesophageal reflux disease in the switch drug group was 13.14%,which was higher than that in the non-switch drug group (8.28%).The average number of prescriptions in the switch drug group was higher than that in the non-switch drug group (3.88±2.61 vs 2.81±1.88,P<0.05),the proportion of users with ≥ 4 prescriptions in the switch drug group was nearly three times than that of the non-switch drug group.The average duration of treatment in the switch drug group was (47.13±42.39) d,which was longer than that in the non-switch drug group (P<0.05).The frequency of use,defined daily cost and drug utilization index of PPI in the switch drug group were higher than in the non-switch drug group.CONCLUSION PPI users in the switch drug group have more proportion,more prescriptions per year,longer duration,and higher intensity.Clinical doctors and pharmacists should optimize the clinical use of PPI and strengthen the education of drug safety,reduce the disadvantages of drug switching and improve the clinical value of PPI.