Study on Rational Drug Use Evaluation in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease by PCNE Classification System

OBJECTIVE To find out the situation of rational use of drugs for type 2 diabetes mellitus(T2DM) patients with chronic kidney disease(CKD) by using the classification system of pharmaceutical care network of Europe(PCNE). METHODS The 120 discharged medical records for T2DM patients with CKD who were hospitalized in the department of endocrinology in Baoding No.1 Central Hospital from January to April 2021 were retrieved. The medical orders in the cases were reviewed retrospectively by cross-sectional study design, and the drug-related problems(DRPs) were classified and summarized according to PCNE classification system. RESULTS A total of 101 DRPs were found in 120 patients, including 51, 38 and 12 problems with treatment safety, treatment effect and other aspects respectively. The top three causes of DRPs were drug selection, dose selection and drug use process. CONCLUSION In the course of drug treatment for T2DM patients with CKD, clinical pharmacists in endocrine department can strengthen intervention measures, such as strengthening the selection of drugs based on renal function, the adjustment of dosage and frequency, and the analysis of drug interaction, so as to prevent the recurrence of similar DRPs and ensure the safety of medication for patients.