Effect of Beclomethasone Combined with Pulmonary Surfactant on the Prevention and Treatment of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants

OBJECTIVE To explore the effect of beclomethasone combined with pulmonary surfactant (PS) on the prevention of bronchopulmonary dysplasia (BPD) in very low birth weight infants.METHODS One hundred and ten cases of very low birth weight infants with respiratory distress syndrome with body weight<1 500 g and fit for gestational age admitted to Shandong Weifang People's Hospital Affiliated to Shandong Weifang Medical University from June 2017 to June 2020 were selected.All of them were randomly divided into 2 groups.The treatment group was treated with beclomethasone and PS intratracheal instillation,while the control group was treated with only PS intratracheal instillation,oxygen index (OI),failure rate of extubation,rate of invasive ventilation,incidence of BPD,time of suction machine use,time of oxygen use,time of hospitalization,mortality and related complications were recorded and analyzed.RESULTS There was no difference in OI between the treatment group and control group before and on the first day of administration.OI in the treatment group was lower than that in the control group on the 3rd,5th day of administration.The extubation failure rate,invasive ventilation rate,BPD incidence in the treatment group was lower than that in the control group,and the ventilator use time,oxygen use time and hospital stay were lower than those in the control group,with significant differences (P<0.05).There was no significant difference in mortality and complication rate between the two groups.CONCLUSION Beclomethasone combined with intratracheal instillation of PS can effectively reduce the incidence of BPD in very low birth weight infants,and the efficacy is better than that of intratracheal instillation of PS without increasing related complications.