Optimization and Analysis of Treatment Program for a Burkitt Lymphoma Pediatric Patient with Hand Skin and Soft Tissue Infection After Chemotherapy

OBJECTIVE To provide methods and ideas for anti-infection treatment of a burkitt lymphoma child patient with hand skin and soft tissue infection(SSTI) after chemotherapy. METHODS The clinical pharmacist optimized the anti-infection regimen of a burkitt lymphoma child patient with hand SSTI admitted to Children's Hospital of Jinan, the choice of initial antibiotics and the replacement of drugs follow-up aiming at the child's infection of methicillin-resistant Staphylococcus aureus(MRSA), in the process of treatment, the selection of antibiotics in severe agranulocytosis state, the dose adjustments of piperacillin tazobactam, and the frequency determination of teicoplanin were proposed. RESULTS When considering MRSA infection, linezolid was firstly selected, and then replaced with teicoplanin a ccording to the platelet level, and the frequency was determined as the first three doses of 160 mg, infusion pump, q12h, followed by the dose of 160 mg, infusion pump, qd. When the pediatric patients in the state of severe agranulocytosis, imipenem and cilastatin sodium and micafungin were used for anti-infection treatment. According to the guidelines and pharmacokinetic/pharmacodynamic theory, the dose of piperacillin tazobactam was adjusted from 1.2 g, ivgtt, q8h to 1.8 g, ivgtt, q8h, and the infusion time was extended to 3 h. The physician adopted the above recommendations. After effective anti-infection and symptomatic treatment, the symptoms and signs of the pediatric patients were significantly improved, and the pediatric patients was discharged with stable condition. CONCLUSION Participating in the treatment of a child patient with hematological malignancy complicated with infection, clinical pharmacists can make the individual treatment plans according to the specific changes of the disease, put forward the r ational medication suggestions.