Advances in Research on Pyroptosis and Lung Cancer

Pyroptosis is a form of inflammatory necrosis caused by inflammatory bodies. It is characterized by caspase mediated activation of inflammatory cytokines and Gasdermin family proteins, resulting in membrane pore formation, cell swelling, plasma membrane lysis, chromatin fragmentation and release of intracellular pro-inflammatory contents. Inflammatory corpuscles exist in a variety of tumor cells. Inflammatory corpuscles can affect tumor proliferation, invasion and metastasis by mediating cell death. It is found that cell death is closely related to the pathogenesis, progress, prognosis and drug resistance of lung cancer. Summarizing the molecular mechanism of cell death and its research progress in the treatment of lung cancer is helpful to provide a new basis for the diagnosis and treatment of lung cancer and the development of new drugs.