Exploration on the Safety of Drugs for Children Prone to Severe Adverse Reactions Based on the Evaluation Database

OBJECTIVE To explore safety of drugs for children prone to severe adverse reactions based on the evaluation database.METHODS According to the scoring method in the "Quick Guide for Drug Evaluation and Selection in Chinese Medical Institutions", the drugs with 1 or 2 adverse scores under "Safety" in the database of drug comprehensive evaluation of Hebei General Hospital were extracted, first, all the drugs in the hospital with 4-5 grade adverse drug reactions and the incidence rate ≥ 1% were extracted, that was, the drugs with 1 or 2 grade adverse drug reactions were obtained. Secondly, based on the evaluation scores of these drugs in the category of "Child Suitability", the safety of drugs that was prone to serious adverse reactions in children's drugs was explored, that was, a score of 0 indicated that the drug was banned in children, a score of 2 indicated that the drug was available to children. RESULTS There were 18 drugs with ≥ 10% adverse drug reactions, including 15 drugs for tumor and 3 drugs for immunosuppressants. Thirteen drugs were available for children and 5 were banned. The incidence of serious adverse reactions ranged from 1% to 10%. There were 73 drugs including 57 drugs for tumor, 11 drugs for pain relief, 2 drugs for anesthesia, 1 drug for treatment of mental disorders, 1 drug for blood system and 1 drug for ophthalmology. Of these, 30 were available for children and 43 were banned. CONCLUSION Through the extraction of drugs with 1 or 2 points under "Adverse Reactions" in the quantitative evaluation system, the common drugs with serious adverse reactions in the whole hospital are obtained, the feasibility of the use of these drugs in children is analyzed, the use of mini program, information means for clinical children to provide reference of drug use.