Divided-dose Operation of Neonatal Medicines and Its International Management Status

As a special population in pediatrics, neonatal pharmacokinetics and pharmacodynamics are very different from adults due to their physiological characteristics. The drug dose is highly variable and has the characteristics of gestational age and body weight dependence. At present, many dosage forms are not suitable for neonatal treatment. Generally, they can be improved by sub-dosing operation of children or adults, temporary preparation of liquid preparations and other issues. This article mainly summarized the current status of the domestic and foreign neonatal drug administration and related operating norms and standards, aiming to provide a reference for the domestic neonatal divided dose operation and improve the safety and accessibility of domestic neonatal medication.