Study on the Differences in Plasma Concentration, Efficacy and Safety of Lacosamide in Xinjiang Uygur and Han Nationality Pediatric Patients with Epilepsy

OBJECTIVE To explore the correlation and difference between the lacosamide(LCM) plasma concentration and efficacy in children with epilepsy in Xinjiang Uygur and Han nationality pediatric patients. METHODS The plasma concentration of 100 and 194 children with epilepsy in Uygur and Han nationality pediatric patients were determined by ultra-high performance liquid chromatography, and their curative effects and adverse reactions were observed. Logistic regression and receiver operating characteristic curve were used to analyze the correlation between plasma concentration and curative effect in pediatric patients. RESULTS The effective rate of LCM treatment in Uygur nationality pediatric patients was significantly lower than that in Han(65.00% and 78.68%, P<0.05). The plasma concentration of LCM in Uygur nationality pediatric patients were significantly higher than those in Han(7.13±2.88)μg·mL^-1 and (6.27±2.53)μg·mL^-1, P<0.05. The proportion of children receiving LCM monotherapy in the Uyghur and Han effective groups was significantly higher than that in the ineffective group and the proportion of children receiving LCM combined with cytochrome P450 enzyme inducers was significantly lower than that in the ineffective group(P<0.05). The incidence of adverse reactions in Uygur and Han nationality pediatric patients were 29.00% and 36.60%, respectively. The LCM plasma concentration of Uygur pediatric patients with adverse reactions was significantly higher than that of children without adverse reactions(8.20±3.60)μg·mL^-1 and (6.70±2.43)μg·mL^-1,P<0.05. CONCLUSION During the clinical use of LCM to treat children with epilepsy of different ethnic groups, it is necessary to monitor the steady-state trough concentration of LCM to improve the efficacy and reduce the incidence of adverse reactions.