Progress of Clinical Trials and Application of Immune Checkpoint Inhibitors for Pediatric Malignancy

In recent years, the monotherapy and combination therapy of immune checkpoint inhibitors(ICIs) have achieved obvious efficacy in some adult malignancies. However, the efficacy and safety in pediatric malignancies are still uncertain. Early clinical trials of monotherapy and combination therapy in pediatric tumors have been reported successively. This article reviewed the existing literatures and summarized the progress in clinical trials and application of immune checkpoint inhibitors in pediatric tumors in the recent years. The efficacy and safety of ICIs in children with malignant tumors was also elucidated, in order to provide reference for clinical drug use