Research Progress of Pregnane X Receptor in Kidney Disease

Nuclear receptors are a group of transcription factors that widely distributed in the body and play an important role in both physiological and pathological processes. Pregnane X receptor(PXR) is a member of the nuclear receptor family, which is mainly involved in various biological activities, especially in drug metabolism. Kidney is one of the main organs that take part in the regulation of drug metabolism. PXR is involved in various regulation such as renal drug metabolism and transport, and is involved in the pathophysiological process of various kidney diseases. In recent years, researchers have focused on the effects of PXR and its regulatory functions in kidney and renal diseases. This review mainly discusses the role of PXR on renal physiology, the interaction of PXR and the drug metabolic enzymes and its functions in pathological process in renal diseases.