Advances in miRNA-mediated TLR4 Inflammatory Signaling Pathway in Radiation Injury

Radiotherapy is currently recognized as one of the major treatments for various tumors worldwide, but the various types of radiation produced during radiotherapy can cause inflammatory damage to the normal tissues surrounding the radiation. Therefore, it is imperative to explore effective therapeutic targets to improve the inflammatory damage caused by radiation and enhance the efficacy of radiotherapy. It has been found that microRNA(miRNA), a novel inflammatory regulator, regulates radiation-induced inflammatory responses mainly through the TLR4-mediated NF-κB signaling pathway. Therefore, the interactive network system formed by miRNAs and TLR4 is expected to be a screening target for the development of drugs against radiation damage. This review summarizes four aspects, including the regulatory role of TLR4-mediated inflammation-related signaling pathway on radiation, the regulatory role of miRNA on radiation and the targeting role of miRNA on TLR4/NF-κB signaling pathway-regulated inflammatory response in radiation, in order to find effective targets for miRNA-targeted regulation of TLR4-mediated NF-κB signaling pathway and provide new ideas for the prevention and treatment of radiation injury.