Correlation Between Amisulpride Blood Concentration and Adverse Reaction, Prolactin Level and Cognitive Function in Patients with Schizophrenia

OBJECTIVE To observe the efficacy of amisulpride on patients with schizophrenia and the correlation between its blood concentration and adverse reaction, prolactin level and cognitive function. METHODS The 80 patients with schizophrenia who underwent amisulpride monotherapy were selected between July 2019 and June 2020 and were given continuous treatment for 8 weeks. At the end of 1 week, 2 weeks, 4 weeks and 8 weeks of treatment, the dosage of drug, blood concentration, efficacypositive and negative symptom scale(PANSS) and adverse reactiontreatment emergent symptom scale(TESS) were monitored among the patients. At the end of 8 weeks of treatment, the level of serum prolactin was detected, and the cognitive function levelwechsler memory scale-revised in China(WMS-RC), wisconsin card sorting test(WCST) was measured, and the correlation between blood concentration and drug dosage, efficacy, adverse reaction, serum prolactin and cognitive function was analyzed. RESULTS Pearson correlation analysis showed that the blood concentration was positively correlated with PANSS score reduction rate, positive symptom score reduction rate, negative symptom score reduction rate, psychopathology score reduction rate and TESS score at the end of week 1, weeks 2, weeks 4 and weeks 8 of treatment(P<0.05). At the end of weeks 8 of treatment, the level of serum prolactin of male patients and female patients was significantly higher than the baseline day (P<0.05), and the blood concentration of amisulpride in female patients was positively correlated with serum prolactin(P<0.05). At the end of weeks 8 of treatment, the memory quotient(MQ) of WMS-RC test was significantly higher than the baseline day (P<0.05), and the number of responses required for the first classification(R1st) of WCST test was significantly lower than the baseline day while the number of completed classification(Cc) was significantly higher than the baseline day(P<0.05), but the blood concentration of amisulpride was not significantly correlated with MQ, R1st and Cc. CONCLUSION The blood concentration of amisulpride in patients with schizophrenia is correlated with efficacy, adverse reaction and prolactin level in female patients. It is necessary to monitor the blood concentration of patients to further guide the individualized medication.