Research Progress of Role of Cellular Senescence in the Pathogenesis and Treatment of Alzheimer’s Disease

Senescence is the most important factor that leading to neurodegenerative diseases. Cellular senescence will cause the accumulation of cellular and molecular damage, which leads to the failure of the overall repair of the body, ultimately leading to the failure of the body’s aging. Many studies showed that senescence plays an important role in the pathogenesis of Alzheimer’s disease(AD), such as the senescence of astrocyte, microglia, oligodendrocyte progenitor cell, oligodendrocyte, neural stem cell, neurons and endothelial cell, innate immune cell and adaptive immune cell. It is beneficial for AD therapy to eliminate senescent cells and to regulate senescence-related secretory phenotypes. This paper reviewed the role of cell senescence in the pathogenesis of AD and the research progress in the treatment of cell senescence. This may provide clues for further revealing the pathogenesis and studying the prevention and treatment of AD.