Discussion of Professional Consensus on the Technical Practice of the in Vitro Permeation Test for Topical and Transdermal Preparations

In vitro permeation test(IVPT) is one of the important tests for evaluating topical and transdermal preparations. The test results are critical to the prescription screening and consistency evaluation of generic drugs and reference products. The operations of IVPT are complicated and there are many influencing factors, which make unreliable results as well as affect the evaluation of quality, effectiveness and safety for topical and transdermal preparations. Therefore, it is necessary to standardize the IVPT method. Based on the international and domestic progress of this field, the Transdermal Drug Administration Committee of the World Federation of Chinese Medicine Societies organized the experts to discuss and finally formed this consensus for the reference of industry colleagues and supervision departments.