Research Progress of mRNA Vaccine Technology and COVID-19 mRNA Vaccine

The development of mRNA vaccine is limited by conditions such as unstable molecules, high auto-immunogenicity and low delivery efficiency in vivo. After more than 30 years of research, with maturing technology in terms of stable and efficient delivery system, obvious progresses have been made in the fields against tumors or infectious diseases. Compared to the traditional vaccine, this technology can induce both humoral and cellular immunities. It is characterized as a technique with simple production technology, short research and development cycle, low cost and easy for standard manufacturing, which makes it suitable for the developing and production in the time of pandemic or outbreak of infectious diseases and has broad prospects. In the circumstance of the current global pandemic of COVID-19, this review analyzes and describes the characteristics and delivery system of mRNA vaccine in this paper, combined with its research situation on COVID-19,thus to provide references for the subsequent mRNA vaccine research and development.