Research Progress of Novel Formulations of Cannabidiol

Cannabidiol(CBD) is a non-addictive ingredient extracted from the plant cannabis. In recent years, many studies have shown that CBD has a variety of pharmacological effects and high safety, including anti-epileptic, anti-convulsant, treatment pain, anti-inflammatory and neuroprotective properties. Due to the inherent properties of CBD with high lipophilicity, low water solubility and easy first-pass metabolism, it leads to low oral bioavailability and reduces the clinical efficiency of CBD, which is not conducive to its use as a conventional preparation. This article mainly reviews the research on novel formulations that improve the solubility and bioavailability of CBD in recent years, and expounds the experimental research on new technologies such as transdermal delivery systems, transmucosal delivery systems, self-emulsifying delivery systems and new solid formulations to improve the solubility and bioavailability of CBD, and research tendency and developing prospects were also outlined.