Research Progress on Virtual Screening of Bacterial Quorum Sensing Inhibitors in Natural Products

Quorum sensing is a hot topic in microbiology in recent years. With the deepening of quorum sensing research, various quorum sensing inhibitors have emerged. Virtual screening is an active compound screening method based on small molecule database. It is an effective method to search for lead compounds, discover drug structure-activity relationships, optimize drug design, and discover drug targets. Virtual screening has the advantages of low cost and high efficiency, and it has a good application prospect in screening quorum sensing inhibitors research. In this paper, based on the types of bacterial quorum sensing signaling molecules, the current research status of screening quorum sensing inhibitors from natural products by virtual screening technology was reviewed.