Meta-analysis of Blood Lipid Level in the Treatment of Angina Pectoris with Salvia Miltiorrhiza Ligustrazine Hydrochloride Injection

OBJECTIVE To evaluate the efficacy and safety of Salvia Miltiorrhiza Ligustrazine Hydrochloride injection in the treatment of angina pectoris and its effect on hyperlipidaemia. METHODS Cochrane Library, Pubmed, Embase, CNKI, WanFang Data, VIP and other databases were searched by computer, and the searched time was from the database to February 19, 2021. Two researchers independently screened the literature, extracted the data and evaluated the risk of bias. Meta-analysis was performed by RevMan5.3 software.RESULTS Sixteen randomized controlled trials with 1 631 patients were included. The results of meta analysis showed that, compared with conventional western medicine, combined with Salvia Miltiorrhiza Ligustrazine Hydrochloride injection had better total efficacyOR=3.88, 95% CI(2.80, 5.37), P<0.000 01 in the treatment of angina. The levels of total cholesterolMD=-1.08, 95%CI(-1.36, -0.81), P<0.000 01, total triglycerideMD=-0.52, 95%CI(-0.66, -0.37), P<0.000 01 and low density lipoproteinMD=-0.74, 95%CI(-0.94, -0.55), P<0.000 1 in Salvia Miltiorrhiza Ligustrazine Hydrochloride injection group were lower than those in control group. The level of high density lipoprotein in Salvia Miltiorrhiza Ligustrazine Hydrochloride injection group was higher than that in control groupMD=0.28, 95%CI(0.20, 0.36), P<0.000 01. The incidence of adverse reactions of Salvia Miltiorrhiza Ligustrazine Hydrochloride injection group was lower than that of the control groupOR=0.57, 95%CI(0.30, 1.08), P=0.008.CONCLUSION Treatment combined with Salvia Miltiorrhiza Ligustrazine Hydrochloride injection has significant curative effect on angina pectoris and can effectively improve blood lipid level without increasing the incidence of adverse reactions.