Research Progress of Mucoadhesive Buccal Films

In recent years, many studies have proved that mucoadhesive buccal films(MBFs) exhibit high bioavailability and high compliance in systemic or local drug delivery, and have the advantage of low preparation difficulty and have the ability to terminate drug delivery at any time. MBFs have become the most industrialized buccal mucosal drug delivery system. Drugs are dissolved or dispersed in film-former to prepare MBFs by various preparation processes. The mechanical properties of MBFs directly affect their application, but there is no standard characterization method at present. Therefore, this article reviews the MBFs that have been marketed and under research in recent years from the three aspects of prescription screening, preparation process and quality evaluation, and summarizes the existing problems at this stage, aiming to promote their development and the process of industrialization.