Explore on Prescription Regularity for Lacunar Infarction Treated with Traditional Chinese Medicine Based on Data Mining Technology

OBJECTIVE To summarize the medication rules of traditional Chinese medicine(TCM) treatment of lacunar infarction by data mining. METHODS Literature about TCMs formula for lacunar infarction from the database of CNKI, VIP, Wanfang and CBM were searched from the building to May 31, 2020. The TCMISS(V 2.5) was used to analyze the frequency of herb use, flavors and median tropism in prescriptions, commonly used herb-pairs and herb combinations. The association rule, revised mutual information, and complex system entropy clustering in TCMISS(V 2.5) were used to analyze the herb association rules and core herb combinations. The unsupervised entropy hierarchical clustering was used for new prescription analysis. RESULTS A total of 231 formulas were included, 242 kinds of TCMs were involved. TCMs with higher frequency were Chuanxiong Rhizoma, Salviae Miltiorrhizae Radix et Rhizoma, Astragali Radix, Pheretima and other 41 kinds. The main four properties were mainly warm, cold and mild, the five flavors are mainly concentrated in sweet (light), bitter and spicy, and the meridian tropism were mainly liver, spleen, and lung. The 48 high-frequency herb combinations were obtained, and the top 6 combinations with frequency from high to low were Chuanxiong Rhizoma-Astragali Radix, Chuanxiong Rhizoma-Pheretim, Chuanxiong Rhizoma-Angelicae Sinensis Radix, Salviae Miltiorrhizae Radix et Rhizoma-Pheretim, Astragali Radix-Pheretim and Chuanxiong Rhizoma-Salviae Miltiorrhizae Radix et Rhizoma. A total of 16 core herb combinations and 8 potential new prescriptions were obtained. CONCLUSION The overall treatment of lacunar infarction with TCMs was to tonifying Qi, removing blood stasis and dredging collaterals.