Study on the Preparation of Baihua Xianglian Jiedu Granules

OBJECTIVE To optimize the preparation process of Baihua Xianglian Jiedu granules. METHODS The best extraction technology of Baihua Xianglian Jiedu granules was optimized by orthogonal test, with the specific component of deacetyl asperulosidic acid methyl ester of Hedyotis diffusa and the extract rate as the index. Based on the indexes of molding rate, solubility and fluidity, the conditions of excipients, dosage and technology were investigated to determine the molding technology of the prescription. RESULTS The best extraction process of Baihua Xianglian Jiedu granules was:add 10 times of water, extract twice, each time for 1.5 h; the molding process was add dextrin according to the proportion of thick paste:dextrin=1:2, take 0.25% aspatan and 0.25% stevia of the mixture of dextrin thick paste as the flavoring agent, then add 45% ethanol as the wetting agent, mix well, sift through 14 mesh, dry by air at 80℃, and complete the granules. CONCLUSION The optimized preparation technology is stable, simple and feasible, which can provide reference for the preparation and production of Baihua Xianglian Jiedu granules.