Research Progress on the Protective Effect and Mechanism of Resveratrol on Gametogenesis

Resveratrol is a natural non-flavonoid polyphenolic compound, which has lots of pharmacological effects, including anti-inflammatory, antioxidant, anti-apoptosis, cardiovascular protection and et al, which has positive therapeutic effects on various diseases of the body. In this study, the protective effects of resveratrol on folliculogenesis, oocyte and embryo development and spermatogenesis under adverse factors such as physicochemical factor and metabolic disturbance were summarized. At the same time, this paper reviews the relevant mechanisms of resveratrol regulating the hypothalamus-pituitaries-gonadal axis, oxidative stress, PI3K/Akt et al. Signaling pathways and epigenetic modification, so as to provide theoretical reference for the application of resveratrol in improving clinical infertility caused by follicular development and spermatogenesis disorders.