Clinical Study of Baibo Tincture Combined with 308 nm Excimer Laser in the Treatment of Vitiligo with Liver and Kidney Deficiency

OBJECTIVE To observed the clinical efficacy of baibo tincture combined with 308 nm excimer laser in the treatment of vitiligo with liver and kidney deficiency. METHODS A total of 128 patients with vitiligo(traditional Chinese medicine syndrome of deficiency of liver and kidney) received in Taizhou Hospital of Zhejiang Province from March 2017 to March 2019 were divided into observation group and control group according to random number table method, with 64 cases in each group. The control group was treated with 308 nm excimer laser, and the observation group was treated with baibo tincture on the basis of this, and the treatment courses of both two groups were 12 weeks. The curative effect of the two groups was observed, and the traditional Chinese medicine symptoms, DLQI score, pigmentation score, skin lesion area, and first color rendering time were compared and analyzed. Meanwhile, the levels of basic fibroblast growth factor(bFGF), tumor necrosis factor-α(TNF-α), interferon-γ(IFN-γ), CXC chemokine ligand 10(CXCL10) were detected. The occurrence of adverse effects during treatment was recorded while a one-year follow-up was conducted to compare recurrence rates. RESULTS After treatment, the total effective rate and excellent efficiency of the observation group were 85.94% and 65.63% higher than the control group 78.13% and 45.31%(P<0.05). Compared with the control group, traditional Chinese medicine symptoms and DLQI scores in the observation group were lower(P<0.05). The pigmentation integral and skin lesion area in the observation group were lower(P<0.05), and the time of first color restoration was shorter(P<0.05). The levels of bFGF in the observation group were higher(P<0.05), and the levels of TNF-α, CXCL10 and IFN-γ were lower(P<0.05). The overall recurrence rate was 4.69% in the observation group, which was lower than the rate of 18.75% in the control group(P<0.05). CONCLUSION Baibo tincture combined with 308 nm excimer laser treatment can effectively improve the clinical symptoms of vitiligo with liver and kidney deficiency patients, regulate the levels of bFGF, TNF-α, CXCL10, IFN-γ, improve the quality of life of patients, with good long-term efficacy, which is worthy of clinical application.