Determination of Sulfur in Brominated Butyl Rubber Gasket and Its Migrating Research to Drugs

OBJECTIVE To establish a method for the determination of sulfur in brominated butyl rubber gasket and its migrating research to Qingxin'anshen oral liquid by HPLC. METHODS The Dikma Diamonsil C₁₈column(250 mm×4.6 mm, 5 μm) was used with the mobile phase of acetonitrile-tetrahydrofuran-water(60:30:10). The wavelength was 272 nm. The column temperature was 30℃. The flow rate was 1.0 mL·min^-1. RESULTS The calibration curve of sulfur was linear over the range of 0.023-233.228 μg·mL^-1(r=0.999 9). The limit of quantification was 0.023 32 μg·mL^-1. The detection limit was 0.005 831 μg·mL^-1. The sample recovery rate was 93.4%, and the migration recovery rate was 95.6%. CONCLUSION The method is simple, rapid, accurate, reliable and reproducible. It can be used for the determination of elemental sulfur in brominated butyl rubber gaskets, and provides an experimental basis for the determination of elemental sulfur in the national pharmacopoeia.